Numerous clinical publications discuss the benefits of Cortex mixed media markers.

Polymark

Fiducial markers visibility and artefacts in prostate cancer radiotherapy and multimodality imaging

“If volumetric imaging using CT, CBCT and MRI is used, then the polymer marker was shown to have the least significant artefacts while maintaining good visibility on the images.”

Right tumor, right time: Systematic methodology for fiducial marker placement to achieve reliable and reproducible image guided (IG) delivery of intratumoral immunotherapy into deep/visceral (D/V) lesions and target-lesion imaging follow-up.

“On Day 1 of Cycle 1, index and treatment lesions were labeled with a fiducial (PolyMark, CIVCO Medical Solution, Orange City, IA) prior to biopsy of both lesions and ITI of IMO-2125 into the treatment lesion. . . . Fiducial placement facilitates reliable visualization of target and control tumors over the course of a multiple cycles of D/V ITI.”

Quantitative Evaluation of Fiducial Markers for Radiotherapy Imaging

“The polymer marker causes minimal artifacts in CT and CBCT but has poor visibility in EPID-MV.”

Fleximarc G/T

An evaluation of systematic errors on marker-based registration of computed tomography and magnetic resonance images of the liver

“A close arrangement of the markers to the tumour would decrease the set up systematic error to 0.6 mm for liver compression and 0.4 mm for free-breathing.”

General

Fiducial markers and spacers in prostate radiotherapy: current applications

“Fiducial markers are now considered standard of care in the delivery of modern prostate RT, and their use is recommended especially when considering dose escalation. Fiducials are an excellent surrogate for prostate position and allow for accurate treatment delivery and minimise the radiation dose to the surrounding organs. Severe complications from fiducial implantation are uncommon, marker loss is rare and marker migration is clinically insignificant.”

2D kV orthogonal imaging with fiducial markers is more precise for daily image guided alignments than soft-tissue cone beam computed tomography for prostate radiation therapy

“The kV-FM–based daily IG alignment for IMRT of prostate cancer is more precise than ST-CBCT, as assessed by a physician's ability to reproducibly align images. Given the magnitude of the error introduced by inconsistency in making ST-CBCT alignments, these data support a role for daily kV imaging of FM to enhance the precision of external beam dose delivery to the prostate.”